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Benzocaine

Indications and Usage Uses synthesis
Benzocaine
Benzocaine structure
CAS No.
94-09-7
Chemical Name:
Benzocaine
Synonyms
Solu H;Norcain;Ora-jel;Ethoform;Norcaine;Topcaine;NSC 4688;ORTHESIN;Euphagin;Anestezin
CBNumber:
CB1217951
Molecular Formula:
C9H11NO2
Formula Weight:
165.19
MOL File:
94-09-7.mol

Benzocaine Properties

Melting point:
88-90 °C
Boiling point:
172 °C (12.7517 mmHg)
Density 
1.17
refractive index 
1.5600 (estimate)
Flash point:
172°C/13mm
storage temp. 
0-6°C
solubility 
alcohol: soluble1 gm in 5 ml
form 
Crystalline Powder
pka
2.5(at 25℃)
color 
White
Water Solubility 
Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water
Merck 
14,1086
BRN 
638434
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
BLFLLBZGZJTVJG-UHFFFAOYSA-N
CAS DataBase Reference
94-09-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 4-amino-, ethyl ester(94-09-7)
EPA Substance Registry System
Benzoic acid, 4-amino-, ethyl ester(94-09-7)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,T,F
Risk Statements  43-36/37/38-39/23/24/25-23/24/25-11
Safety Statements  22-24/25-37/39-26-24-45-36/37-16-7
RIDADR  3077
WGK Germany  2
RTECS  DG2450000
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29224995
Hazardous Substances Data 94-09-7(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P391 Collect spillage. Hazardous to the aquatic environment
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Benzocaine price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 06952 Benzocaine tested according to Ph.Eur. 94-09-7 100g $82.4 2018-11-13 Buy
Sigma-Aldrich 1054000 Benzocaine United States Pharmacopeia (USP) Reference Standard 94-09-7 500mg $348 2018-11-13 Buy
TCI Chemical A0271 Ethyl 4-Aminobenzoate >99.0%(GC)(T) 94-09-7 25g $17 2018-11-22 Buy
TCI Chemical A0271 Ethyl 4-Aminobenzoate >99.0%(GC)(T) 94-09-7 500g $106 2018-11-22 Buy
Alfa Aesar A12754 Ethyl 4-aminobenzoate, 98% 94-09-7 250g $46.2 2018-11-13 Buy

Benzocaine Chemical Properties,Uses,Production

Indications and Usage

Benzocaine is a colorless trapezial crystal. Its melting point is 92℃ (88-90℃), boiling point is 183-184°C (1.87kPa). 1g of this drug is soluble in about 2500ml water, 5ml ethanol, 2ml chloroform, 4ml ether or 30-50ml almond oil and olive oil, and it is also soluble in dilute acid. It is stable in air, odorless, and slightly bitter.
Benzocaine is a lipid-soluble surface anesthetic, and it weaker than other local anesthetics such as lidocaine and tetracaine, so it will not cause any discomfort due to its anesthetizing effects when acting on mucosa. Benzocaine is a type of drug with relatively strong lipid-solubility and will bind with mucosa and the fatty layer of skin, but it will not easily penetrate into the body and cause poisoning. Benzocaine can be used as a precursor for Ossur imitation, orthocaine, and procaine. It is also used as a local anesthetic and can stop pain and itching. It is mainly used in pain and itch prevention on wounds, ulcer surfaces, mucous membrane surfaces and hemorrhoids. Its paste form can also lubricate and stop pain for the nasopharynx and endoscope. Benzocaine’s aural solution is used to alleviate acute congestion, concentrated otitis externa, and the pain and itching of swimming otitis. Benzocaine is also effective for toothaches, sore throat, oral ulcers, all kinds of hemorrhoids, anal fissures, and vulvar itching. Benzocaine can be used as a male sex organ numbing agent to slow ejaculation. It can also be used as a numbing lubricant for the pharynx and endoscope, and it can be used as a UV absorbing agent for cosmetics.

Uses

  1. Benzocaine is a local anaesthetic of the ester type with a poor solubility in water. The drug benzocaine is normally used as a topical pain reliever or as a common ingredient in cough drops. Benzocaine is used in multiple forms including lotion, gel, liquid, lozenges, and sprays. When Benzocaine is applied in any form it temporarily numbs or blocks the nerve endings, which leads to a decreases in the amount of pain. It is used in cattle, sheep, swine and horses for local and prolonged low epidural anaesthesia. Standard therapeutic doses of benzocaine ranged from 150 to 750 mg per animal. Benzocaine is also currently used as surface anaesthetic as ointments (0.5% benzocaine) for wounds and ulcerated surfaces in horses, cattle and sheep applied twice a day until healing.
  2. A commonly used topical pain reliever. Main active ingredient in anesthetic ointments.
  3. Anesthetic;Na+ channel blocker
  4. Benzocaine acts on the central nervous system, cardiovascular system, neuromuscular junctions and ganglion synapse. Its mechanism of action is to prevent the generation and conduction of the nerve impulse. Local anaesthetics block conduction by decreasing or preventing the large transient increase in the permeability of excitable membranes to Na+ that is produced by a slight depolarisation. This action of local anaesthetics is due to their direct interaction with voltage-sensitive Na+ channels. Benzocaine is mainly hydroxylated in the metabolite para-aminobenzoic acid (PABA) that inhibits the action of sulphonamides.
  5. Benzocaine is distributed in the body, crosses the placenta and is metabolised in the liver and in the plasma by non-specific cholinesterases. Benzocaine and its main metabolite (para-aminobenzoic acid) are excreted into urine.
  6. Benzocaine appears as a moderately toxic compound after single administration. The acute intraperitoneal LD50 value was 216 mg/kg bw in mice. Benzocaine may induce methemoglobinemia in several species such as sheep, cats and dogs.

synthesis

the synthesis of benzocaine is carried out by the acid-catalyzed esterification of 4-aminobenzoic acid with ethanol:
the synthesis of benzocaine
In a 5-mL round bottom flask, add 120 mg of 4-aminobenzoic acid (often called PABA for paminobenzoic acid), 1.5 mL of absolute ethanol (absolute ethanol is completely free of water and can be found on the hooded shevles), and 3 boiling chips. Heat this mixture on a sand bath until all the solid dissolves. Cool in ice and then add 0.25 mL of concentrated sulfuric acid dropwise. (One drop at a time.) A large amount of precipitate will form when the sulfuric acid is added, but this will dissolve during the reflux that follows. Attach an air condenser from the microscale kit, and reflux gently for 60- 75 min. Check periodically to be sure that the mixture is refluxing gently, and that the ring of condensation of solvent lies somewhere along the inner surface of the air condenser; loss of solvent will cause overheating and a significant decrease in yield.

Chemical Properties

white odourless crystals

Uses

Benzocaine is used as an anesthetic (local).

brand name

Americaine (Fisons); Baby Anbesol (Whitehall-Robins).

Biological Functions

Benzocaine is a PABA derivative used primarily for topical application to skin and mucous membranes. Its low aqueous solubility allows it to stay at the site of application for long periods. Its minimal rate of absorption after topical administration is associated with a low incidence of systemic toxicity. Benzocaine is contraindicated in patients with known sensitivity to ester-linked anesthetics or PABA-containing compounds.

General Description

Benzocaine is a unique local anesthetic because it does notcontain a tertiary amine. The pKa of the aromatic amine is 3.5ensuring that benzocaine is uncharged at physiological pH.Because it is uncharged, it is not water soluble but is ideal fortopical applications. The onset of action is within 30 secondsand the duration of drug action is 10 to 15 minutes.

Clinical Use

Benzocaine is used for endoscopy, bronchoscopy, and topicalanesthesia. Benzocaine is available as a 20% solution topicalspray, in a 1% gel for mucous membrane application, and a14% glycerin suspension for topical use in the outer ear.Toxicity to benzocaine can occur when the topical doseexceeds 200 to 300 mg resulting in methemoglobinemia.Infants and children are more susceptible to this and methemoglobinemiahas been reported after benzocaine lubricationof endotracheal tubes and after topical administration to treata painful diaper rash.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by rectal route: methemoglobinemia/carboxyhemoglobinem ia in infants. A skin irritant and a mild sensitizer. Local contact may cause contact dermatitis. Used as a topical anesthetic and as a sun-screening agent. When heated to decomposition it emits highly toxic fumes of NOx. See also ETHYL ALCOHOL and ESTERS

Purification Methods

Crystallise Benzocaine from EtOH/H2O or EtOH (m 93-94o), and dry it in air. [Beilstein 14 H 422, 14 IV 1129.]

Benzocaine Preparation Products And Raw materials

Raw materials

Preparation Products


Benzocaine Suppliers

Global( 431)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 [email protected] CHINA 3202 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 [email protected] China 1819 55
career henan chemical co
+86-371-86658258
[email protected] CHINA 25787 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
[email protected] CHINA 1081 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 [email protected] CHINA 703 58
Hebei Aicrowe Biotech Co., Ltd
0311-66855331
[email protected] CHINA 315 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 [email protected] CHINA 1018 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 [email protected] CHINA 405 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
[email protected] CHINA 21847 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
[email protected] CHINA 272 58

View Lastest Price from Benzocaine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-02 Benzocaine Manufacturer; In stock GMP Factory
94-09-7
US $1.00 / KG 1KG High quality manufacturer TOP 3 largest production factory in China Chemwill Asia Co.,Ltd.
2018-12-16 Benzocaine
94-09-7
US $7.00 / kg 1kg 99% 100kg career henan chemical co
2019-05-15 Benzocaine
94-09-7
US $1.00 / KG 1KG 99% 500 Hebei Aicrowe Biotech Co., Ltd

Benzocaine Spectrum


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