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Phenothiazine

description Chemical Properties side effects Uses Synthesis
Phenothiazine
Phenothiazine structure
CAS No.
92-84-2
Chemical Name:
Phenothiazine
Synonyms
XL-50;ent38;Feeno;Biverm;ENT 38;Orimon;Reconox;PHENOXUR;VERMITIN;Agrazine
CBNumber:
CB2272320
Molecular Formula:
C12H9NS
Formula Weight:
199.27
MOL File:
92-84-2.mol

Phenothiazine Properties

Melting point:
184 °C
Boiling point:
371 °C(lit.)
Density 
1.362
vapor pressure 
0.0000647 Pa (20 °C)
refractive index 
1.6353
Flash point:
202°C
storage temp. 
Store below +30°C.
solubility 
0.127mg/l
form 
Prills or Beads
pka
pKa 2.52 (Uncertain)
color 
Yellow
PH
6 (10g/l, H2O, 20℃)(aqueous suspension)
Water Solubility 
2 mg/L (25 ºC)
Sensitive 
Light Sensitive
Merck 
14,7252
BRN 
143237
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids. May discolour upon exposure to light.
InChIKey
WJFKNYWRSNBZNX-UHFFFAOYSA-N
CAS DataBase Reference
92-84-2(CAS DataBase Reference)
NIST Chemistry Reference
Phenothiazine(92-84-2)
EPA Substance Registry System
10H-Phenothiazine(92-84-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,N,Xn
Risk Statements  36/37/38-43-51/53-36/38-40-20/21/22-52/53-48/22-22
Safety Statements  26-36-61-36/37/39-29-22-36/37
WGK Germany  1
RTECS  SN5075000
8-23
Autoignition Temperature 470 °C
TSCA  Yes
HS Code  29343090
Hazardous Substances Data 92-84-2(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 2000 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P321 Specific treatment (see … on this label).
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.

Phenothiazine price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 88580 Phenothiazine purum, ≥98.0% (GC) 92-84-2 1kg $81.9 2018-11-13 Buy
Sigma-Aldrich 1525707 Phenothiazine United States Pharmacopeia (USP) Reference Standard 92-84-2 500mg $348 2018-11-13 Buy
TCI Chemical P0106 Phenothiazine >98.0%(GC) 92-84-2 25g $16 2018-11-22 Buy
TCI Chemical P0106 Phenothiazine >98.0%(GC) 92-84-2 500g $32 2018-11-22 Buy
Alfa Aesar A12517 Phenothiazine, 98+% 92-84-2 500g $35.3 2018-11-13 Buy

Phenothiazine Chemical Properties,Uses,Production

description

Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors.
Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Chlorpromazine is used also in the treatment of certain types of porphyria, and with other medicines in the treatment of tetanus. Phenothiazines may also be used for other conditions as determined by your doctor.

Chemical Properties

It is clean gray-green powder with the melting point of 185.5 ℃, boiling point of 371 ℃, 290 ℃ (5.33kPa). It is insoluble in petroleum ether, chloroform and water, and soluble in ether and hot acetic acid. It will be oxidized upon exposure to light in the air.

side effects

For more than a decade, phenothiazine drugs have been used to treat a variety of disorders and have proved particularly effective in the treatment of schizophrenia. Clinical experience indicates that initial extremely high dosages are necessary to effect improvement of patients with schizophrenic illnesses.
During 1964, several sequelae have been reported following prolonged high dosage of these drugs. These recent reports refer to side effects which are apparently permanent, in contrast to earlier communications of transient deleterious effects. For example, it has been known for several years that extrapyramidal disorders occur frequently in patients taking phenothiazines; however, a reduction in dosage or cessation of medication appeared to produce a return to the normal state.
Phenothiazines may cause unwanted, unattractive, and uncontrolled face or body movements that may not go away when you stop taking the medicine. They may also cause other serious unwanted effects. You and your doctor should talk about the good this medicine will do as well as the risks of using it. Also, your doctor should look for early signs of these effects at regular visits. Your doctor may be able to stop or decrease some unwanted effects, if they do occur, by changing your dose or by making other changes in your treatment.
These medicines are available only with your doctor's prescription.
Levoprome(R) (methotrimeprazine) is no longer available in the United States. At the end of May 1998, Immunex Corporation stopped marketing it.
Once a medicine has been approved for marketing for a certain use, experience may show that it also is useful for other medical problems. Although these uses are not included in product labeling, phenothiazines are used in certain patients with the following medical conditions:

Uses

Synthesis

22 g of diphenylamine, 8.2 g of sulfur, and 3.2 gms. of anhydrous aluminum chloride are melted together. The reaction sets 140-150° C with the rapid evolution of hydrogen sulfide; by lowerg the temperature, a few degrees the reaction can be slackened. Wen the reaction has moderated, the temperature is raised to 160° C for a time. The melt, when cool, is ground up and extracted, first with water and then with dilute alcohol. The residue consists of almost pure phenothiazine. It can be recrystallised from alcohol. Yield 93%, yellowish leaflets; m.p. 180° C.
Preparation of phenothiazine
Systematic organic chemistry, by W. M. Cumming, 325-326, 1937.

Chemical Properties

Phenothiazine is a greenish-yellow to greenish-gray crystalline substance. Slight odor and taste.

Chemical Properties

yellow or pale green powder

Uses

A key component of antipsychotic and antihistaminic drugs.

Uses

Employed in the preparation of carbazoles and piperazines,1 and charge-transfer semiconducting complexes.2

Uses

A rigid, tricyclic thiazine useful as an electron donor.

Uses

Insecticide; manufacture of pharmaceuticals.

Definition

ChEBI: The 10H-tautomer of phenothiazine.

brand name

Nemazine (Parke-Davis).

General Description

Light green to steel-blue powder. Acquires a greenish-brown tint under exposure to sunlight.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Phenothiazine is slowly decomposed by sunlight. . Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

Fire Hazard

Flash point data for Phenothiazine are not available, but Phenothiazine is probably combustible.

Safety Profile

Poison by intravenous route. Moderately toxic to humans by ingestion. Experimental reproductive effects. An insecticide. Large doses, i.e., heavy exposure, may cause hemolytic anemia and toxic degeneration of the liver. Can cause skin irritation and photosensitization. Dangerous; when heated to decomposition or on contact with acid or acid fumes it emits hghly toxic fumes of SOx and NOx.

Potential Exposure

Phenothiazine is used as an insecticide; as a base for the manufacture of tranquilizers; as anthelmintic in medicine and veterinary medicine; it is used widely as an intermediate in pharmaceutical manufacture; polymerization inhibitor, antioxidant.

Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Purification Methods

Crystallise it from *benzene, toluene, hexane or Me2CO (charcoal) after boiling for 10minutes under reflux. Filter the crystals off and dry them in an oven at 100o, then in a vacuum desiccator over paraffin chips. Also recrystallise it twice from water and dry it in an oven at 100o for 8-10hours. It sublimes at 130o/1mm and has UV with at 253nm in heptane. [Beilstein

Incompatibilities

Organosulfides are incompatible with strong acids and acid fumes; elevated temperatures; sulfur oxides and nitrogen oxides can be produced. Contact with strong reducing agents such as hydrides; azo and diazo compounds, halocarbons, isocyanates can generate heat and may form explosive hydrogen gas

Waste Disposal

Dissolve in combustible solvent and spray into incinerator equipped with afterburner and scrubber. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Phenothiazine Preparation Products And Raw materials

Raw materials

Preparation Products


Phenothiazine Suppliers

Global( 316)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Xiangtong Chemical Co., Ltd.
86-371-61312303
86-371-86017988 [email protected] CHINA 220 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
[email protected] CHINA 21770 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 [email protected] CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 [email protected] CHINA 32447 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 [email protected] CHINA 2758 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 [email protected] CHINA 2543 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 [email protected] China 1849 55
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
[email protected] CHINA 6370 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
[email protected] CHINA 3623 58
career henan chemical co
+86-371-86658258
[email protected] CHINA 27142 58

View Lastest Price from Phenothiazine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-15 Phenothiazine
92-84-2
US $5.00 / KG 1T AS COA 99% 100T Henan Xiangtong Chemical Co., Ltd.
2019-06-27 Phenothiazine
92-84-2
US $10.00 / KG/Tin 1KG 99% 100 career henan chemical co

Phenothiazine Spectrum


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