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8-Hydroxyquinoline

8-Hydroxyquinoline
8-Hydroxyquinoline structure
CAS No.
148-24-3
Chemical Name:
8-Hydroxyquinoline
Synonyms
OQ;8-OQ;Oxin;Tumex;OXINE;8-Oxine;BIOQUIN;NSC 2039;8-Quinol;Fennosan
CBNumber:
CB8435187
Molecular Formula:
C9H7NO
Formula Weight:
145.16
MOL File:
148-24-3.mol

8-Hydroxyquinoline Properties

Melting point:
70-73 °C(lit.)
Boiling point:
267 °C752 mm Hg(lit.)
Density 
1.0340
refractive index 
1.4500 (estimate)
Flash point:
267°C
storage temp. 
Store at RT.
solubility 
0.56g/l
pka
5.017(at 20℃)
form 
Liquid
color 
White to pale yellow or light beige
Water Solubility 
INSOLUBLE
Sensitive 
Light Sensitive
Merck 
14,4843
BRN 
114512
InChIKey
MCJGNVYPOGVAJF-UHFFFAOYSA-N
CAS DataBase Reference
148-24-3(CAS DataBase Reference)
NIST Chemistry Reference
8-Quinolinol(148-24-3)
EPA Substance Registry System
8-Quinolinol(148-24-3)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-68-36/37/38
Safety Statements  45-36/37/39-26-36
RIDADR  2811
WGK Germany  3
RTECS  VC4200000
Hazard Note  Harmful/Irritant
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29334990
Hazardous Substances Data 148-24-3(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 1200 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

8-Hydroxyquinoline price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 252565 8-Hydroxyquinoline ACS reagent, 99% 148-24-3 50g $56.7 2018-11-13 Buy
Sigma-Aldrich 252565 8-Hydroxyquinoline ACS reagent, 99% 148-24-3 1kg $277 2018-11-13 Buy
TCI Chemical H0305 8-Quinolinol >99.0%(GC)(T) 148-24-3 25g $17 2018-11-22 Buy
TCI Chemical H0305 8-Quinolinol >99.0%(GC)(T) 148-24-3 500g $84 2018-11-22 Buy
Alfa Aesar 041272 8-Hydroxyquinoline, ACS 148-24-3 50g $32.6 2018-11-16 Buy

8-Hydroxyquinoline Chemical Properties,Uses,Production

Chemical Properties

Cream-colored crystals

Uses

antiinfectant, complexing agent

Definition

ChEBI: A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.

brand name

Aci-jel;Benzease;Chinosol;Cp-cap;Dermacid;Dermoplast;Fennosan h 30;Heriat;Hydroxybenoxopyridine;Medicone derma-hc;Oxykin;Oxyquinoline-rhp;Pedivol;Phenopyridine;Preconsol;Quinoderm;Quinoped;Quinophenol;Recta medicone-hc;Semori;Serohinol;Serorhinol;Superol;Trimo-san;Triva douch powder;Triva jel.

World Health Organization (WHO)

Halogenated hydroxyquinoline is structurally related to clioquinol. See WHO comment for clioquinol. (Reference: (WHODI) WHO Drug Information, 77.1, 9, 1977)

General Description

White to off-white or faintly yellow crystalline powder. Phenolic odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

8-Hydroxyquinoline darkens on exposure to light. 8-Hydroxyquinoline readily forms stable metal chelates. 8-Hydroxyquinoline is incompatible with strong oxidizers. 8-Hydroxyquinoline is also incompatible with many metal ions.

Hazard

Toxic by ingestion. Questionable carcinogen.

Fire Hazard

Flash point data for 8-Hydroxyquinoline are not available; however, 8-Hydroxyquinoline is probably combustible.

Clinical Use

Oxine, quinophenol, or oxyquinoline is the parent compoundfrom which the antiprotozoal oxyquinolines havebeen derived. The antibacterial and antifungal properties of oxine and its derivatives, which are believed to result fromthe ability to chelate metal ions, are well known. Aqueoussolutions of acid salts of oxine, particularly the sulfate(Chinosol, Quinosol), in concentrations of 1:3,000 to1:1,000, have been used as topical antiseptics. The substitutionof an iodine atom at the 7-position of 8-hydroxyquinolinesyields compounds with broad-spectrum amebicidalproperties.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Experimental reproductive effects. A central nervous system stimulant. Human mutation data reported. Combustible when exposed to heat or flame. When heated to decomposition it emits hghly toxic fumes of NOx.

Purification Methods

Crystallise oxine from hot EtOH, acetone, pet ether (b 60-80o) or water. Crude oxine can be purified by precipitation of copper oxinate, followed by liberation of free oxine with H2S or by steam distillation after acidification with H2SO4. Store it in the dark. It forms complexes with many metals. [Manske et al. Can J Research 27F 359 1949, Phillips Chem Rev 56 271 1956, Beilstein 21 III/IV 1135, 21/3 V 252.]

8-Hydroxyquinoline Preparation Products And Raw materials

Raw materials

Preparation Products


8-Hydroxyquinoline Suppliers

Global( 501)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhengzhou Yuanli Biological Technology Co., Ltd
0086-371-67897895
[email protected] CHINA 124 58
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 [email protected] China 1719 55
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 [email protected] China 19952 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 [email protected] CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
[email protected] CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 [email protected] CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 [email protected] CHINA 32651 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 [email protected] CHINA 2474 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 [email protected] CHINA 24219 60
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 [email protected];[email protected];[email protected];[email protected] CHINA 24118 58

View Lastest Price from 8-Hydroxyquinoline manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-06 8-Hydroxyquinoline
148-24-3
US $1.00 / KG 1KG 99% 1 career henan chemical co

8-Hydroxyquinoline Spectrum


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