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Chlorhexidine digluconate

Chlorhexidine digluconate
Chlorhexidine digluconate structure
CAS No.
18472-51-0
Chemical Name:
Chlorhexidine digluconate
Synonyms
abacil;D00858;septeal;unisept;d-)(2:1;hibidil;placout;corsodyl;disteryl;orahexal
CBNumber:
CB9702888
Molecular Formula:
C34H54Cl2N10O14
Formula Weight:
897.76
MOL File:
18472-51-0.mol

Chlorhexidine digluconate Properties

Density 
1.06 g/mL at 25 °C(lit.)
storage temp. 
2-8°C
solubility 
water: soluble50% (w/v)
form 
Liquid
color 
Colorless
Sensitive 
Light Sensitive
λmax
257nm(H2O)(lit.)
Merck 
14,2091
InChIKey
YZIYKJHYYHPJIB-UUPCJSQJSA-N
CAS DataBase Reference
18472-51-0(CAS DataBase Reference)
EPA Substance Registry System
D-Gluconic acid, compd. with N,N''-bis(4-chlorophenyl)- 3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)(18472-51-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  N
Risk Statements  50/53
Safety Statements  61
RIDADR  UN 3082 9 / PGIII
WGK Germany  -
RTECS  DU1950000
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29252900
HS Code  29252900
Toxicity LD50 in mice (mg/kg): 22 i.v.; 1800 orally (Foulkes)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Chlorhexidine digluconate price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C9394 Chlorhexidine digluconate solution 20% in H2O 18472-51-0 25ml $41.2 2018-11-13 Buy
Sigma-Aldrich C9394 Chlorhexidine digluconate solution 20% in H2O 18472-51-0 100ml $103 2018-11-13 Buy
TCI Chemical C3105 Chlorhexidine Digluconate (20% in Water) 18472-51-0 25mL $20 2018-11-22 Buy
Alfa Aesar 041385 Chlorhexidine digluconate, 20% w/v aq. soln., non-sterile 18472-51-0 25ml $23 2018-11-16 Buy
Alfa Aesar 041385 Chlorhexidine digluconate, 20% w/v aq. soln., non-sterile 18472-51-0 *4x500ml $459 2018-11-16 Buy

Chlorhexidine digluconate Chemical Properties,Uses,Production

Description

Chlorhexidine digluconate solution is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX). Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine.
Chlorhexidine digluconate is a broad spectrum antiseptic. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.

Chemical Properties

Almost colourless or pale-yellowish liquid.

Uses

chlorhexidine digluconate is a preservative generally used in concentrations of 0.01 to 0.1 percent to protect against bacteria. It is unstable at high temperatures. Chlorhexidine digluconate is more widely used in europe than in the united States.

Uses

Hydrogenolysis of benzyl-nitrogen bonds

Uses

Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine digluconate 20% solution is a broad spectrum bacteriostatis antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative. It is very effective against plaque, oral flora including Candida and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. It can be used in antiseptic soap, mouthwash that fights plaque, disinfecting wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.

brand name

Dyna-Hex (Xttrium); Hibiclens (Regent); Peridex (Zila); Periochip (Dexcel); Periogard (Colgate); Prevacare (Johnson & Johnson).

Clinical Use

1,6-Di(4 -chlorophenyldiguanido)hexane gluconate (Hibiclens)is the most effective of a series of antibacterial biguanides originallydeveloped in Great Britain.
The antimicrobial properties of the biguanides were discoveredas a result of earlier testing of these compounds aspossible antimalarial agents. Although thebiguanides are technically not bisquaternary ammoniumcompounds and, therefore, should probably be classifiedseparately, they share many physical, chemical, and antimicrobialproperties with the cationic surfactants. Thebiguanides are strongly basic, and they exist as dications atphysiological pH. In chlorhexidine, the positive charges arecounterbalanced by gluconate anions (not shown). Likecationic surfactants, these undergo inactivation when mixedwith anionic detergents and complex anions such as phosphate,carbonate, and silicate.
Chlorhexidine has broad-spectrum antibacterial activitybut is not active against acid-fast bacteria, spores, orviruses. It has been used for such topical uses as preoperativeskin disinfection, wound irrigation, mouthwashes, andgeneral sanitization. Chlorhexidine is not absorbedthrough skin or mucous membranes and does not causesystemic toxicity.

Chlorhexidine digluconate Preparation Products And Raw materials

Raw materials

Preparation Products


Chlorhexidine digluconate Suppliers

Global( 281)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 [email protected] CHINA 500 55
Panjin Jiahe Shengshi Medical Technology Co., Ltd.
0427-6572122
0427-6572122 [email protected] CHINA 4 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 [email protected] CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
[email protected] CHINA 22116 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 [email protected] CHINA 20784 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 [email protected] CHINA 32643 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 [email protected] CHINA 2544 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 [email protected] CHINA 24219 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 [email protected] China 1741 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
[email protected] CHINA 6409 58

View Lastest Price from Chlorhexidine digluconate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Chlorhexidine digluconate
18472-51-0
US $1.00 / KG 1G 98% 100KG career henan chemical co
2019-04-25 Chlorhexidine digluconate
18472-51-0
US $10.00 / kg 1kg 99% 500tons/month -

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